Endocrine Abstracts

Introduction: Cardiovascular complications are the most relevant cause of mortality in patients with acromegaly.Aims: To evaluate the association of diurnal melatonin profile with arterial hypertension in acromegalic patients.Subjects and methods: Thirty seven patients (15 men and 22 women; aged 18–75 years) with acromegaly were under investigation. Blood samples for GH and, IGF1 were taken in fasting state. 6-Sulfatoxymelaton...

Introduction: Cardiovascular complications are the most relevant cause of mortality in patients with acromegaly.Aims: To evaluate the effects of chronic excess of GH, IGF1 and PRL on blood pressure, heart rate and pulse in patients with active acromegaly.Subjects and methods: Sixty-three patients (22 men and 41 women; aged 18–76 years) with macroadenoma of hypophysis (45 – somatotropinoma, 19 – somatomammotropinoma) ...

Variants of ADIPOQ have been inconsistently associated with adiponectin level in diverse populations. We explored association of single nucleotide polymorphism (SNP) in the ADIPOQ (+276 G>T, rs1501299) with circulating total adiponectin and insulin resistance (IR) in Ukrainian T2DM cohort.Materials and methods: 544 T2DM patients (M/F: 241/303, age 56.3±0.4 years, diabetes duration 7.8±1.0 years, BMI 31.7&...